Ontology highlight
ABSTRACT:
SUBMITTER: Dai T
PROVIDER: S-EPMC10175212 | biostudies-literature | 2023 May
REPOSITORIES: biostudies-literature
Dai Tingting T Xie Jinghang J Buonomo Joseph A JA Moreno Angel A Banaei Niaz N Bertozzi Carolyn R CR Rao Jianghong J
Analytical chemistry 20230421 18
Increasingly difficult-to-treat infections by antibiotic-resistant bacteria have become a major public health challenge. Rapid detection of common resistance mechanisms before empiric antibiotic usage is essential for optimizing therapeutic outcomes and containing further spread of resistance to antibiotics among other bacteria. Herein, we present a bioluminogenic probe, D-Bluco, for rapid detection of β-lactamase activity in viable pathogenic bacteria. D-Bluco is a pro-luciferin caged by a β-la ...[more]