Ontology highlight
ABSTRACT:
SUBMITTER: Gerritsen JS
PROVIDER: S-EPMC10176108 | biostudies-literature | 2023 Aug
REPOSITORIES: biostudies-literature
Gerritsen Jacqueline S JS Faraguna Joseph S JS Bonavia Rudy R Furnari Frank B FB White Forest M FM
Life science alliance 20230511 8
The epidermal growth factor receptor (EGFR) has been studied extensively because of its critical role in cellular signaling and association with disease. Previous models have elucidated interactions between EGFR and downstream adaptor proteins or showed phenotypes affected by EGFR. However, the link between specific EGFR phosphorylation sites and phenotypic outcomes is still poorly understood. Here, we employed a suite of isogenic cell lines expressing site-specific mutations at each of the EGFR ...[more]