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Targeted Therapy for SLE-What Works, What Doesn't, What's Next.

ABSTRACT: For many years, the failure of randomized controlled trials (RCTs) has prevented patients with systemic lupus erythematosus (SLE) from benefiting from biological drugs that have proved to be effective in other rheumatological diseases. Only two biologics are approved for SLE, however they can only be administered to a restricted proportion of patients. Recently, several phase II RCTs have evaluated the efficacy and safety of new biologics in extra-renal SLE and lupus nephritis. Six drug trials have reported encouraging results, with an improvement in multiple clinical and serological outcome measures. The possibility of combining B-cell depletion and anti-BLyS treatment has also been successfully explored.

SUBMITTER: Venturelli V

PROVIDER: S-EPMC10179673 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature

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Targeted Therapy for SLE-What Works, What Doesn't, What's Next.

Venturelli Veronica V Isenberg David Alan DA

Journal of clinical medicine 20230429 9

For many years, the failure of randomized controlled trials (RCTs) has prevented patients with systemic lupus erythematosus (SLE) from benefiting from biological drugs that have proved to be effective in other rheumatological diseases. Only two biologics are approved for SLE, however they can only be administered to a restricted proportion of patients. Recently, several phase II RCTs have evaluated the efficacy and safety of new biologics in extra-renal SLE and lupus nephritis. Six drug trials h ...[more]

PMID: 37176637

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