Ontology highlight
ABSTRACT:
SUBMITTER: Lee NH
PROVIDER: S-EPMC10182491 | biostudies-literature | 2023
REPOSITORIES: biostudies-literature
Lee Nien-Hung NH Ma Yi Y Ang Ching-Seng CS Dumesny Chelsea C Huynh Nhi N Yang Yang Y Wang Kai K Nikfarjam Mehrdad M He Hong H
American journal of translational research 20230415 4
Chemoresistance is one of the major causes to the poor prognosis of pancreatic cancer (PC). Gemcitabine alone and gemcitabine-based therapies are mostly used for the treatment of PC. Gemcitabine resistance becomes the focus of chemotherapy. C-X-C motif chemokine 5 (CXCL5), a member of the C-X-C chemokine family, acts through C-X-C chemokine receptor type 2 (CXCR2). A high level of CXCL5 is associated with worse prognosis in PC patients and increased suppressive immune cell infiltration. Increase ...[more]