Dataset Information

Placental microRNAs relate to early childhood growth trajectories.

ABSTRACT:

Background

Poor placental function is a common cause of intrauterine growth restriction, which in turn is associated with increased risks of adverse health outcomes. Our prior work suggests that birthweight and childhood obesity-associated genetic variants functionally impact placental function and that placental microRNA are associated with birthweight. To address the influence of the placenta beyond birth, we assessed the relationship between placental microRNAs and early childhood growth.

Methods

Using the SITAR package, we generated two parameters that describe individual weight trajectories of children (0-5 years) in the New Hampshire Birth Cohort Study (NHBCS, n = 238). Using negative binomial generalized linear models, we identified placental microRNAs that relate to growth parameters (FDR < 0.1), while accounting for sex, gestational age at birth, and maternal parity.

Results

Genes targeted by the six growth trajectory-associated microRNAs are enriched (FDR < 0.05) in growth factor signaling (TGF/beta: miR-876; EGF/R: miR-155, Let-7c; FGF/R: miR-155; IGF/R: Let-7c, miR-155), calmodulin signaling (miR-216a), and NOTCH signaling (miR-629).

Conclusions

Growth-trajectory microRNAs target pathways affecting placental proliferation, differentiation and function. Our results suggest a role for microRNAs in regulating placental cellular dynamics and supports the Developmental Origins of Health and Disease hypothesis that fetal environment can have impacts beyond birth.

Impact

We found that growth trajectory associated placenta microRNAs target genes involved in signaling pathways central to the formation, maintenance and function of placenta; suggesting that placental cellular dynamics remain critical to infant growth to term and are under the control of microRNAs. Our results contribute to the existing body of research suggesting that the placenta plays a key role in programming health in the offspring. This is the first study to relate molecular patterns in placenta, specifically microRNAs, to early childhood growth trajectory.

SUBMITTER: Kennedy EM

PROVIDER: S-EPMC10183479 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature

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Publications

Placental microRNAs relate to early childhood growth trajectories.

Kennedy Elizabeth M EM Hermetz Karen K Burt Amber A Pei Dong D Koestler Devin C DC Hao Ke K Chen Jia J Gilbert-Diamond Diane D Ramakrishnan Usha U Karagas Margaret R MR Marsit Carmen J CJ

Pediatric research 20221115 1

<h4>Background</h4>Poor placental function is a common cause of intrauterine growth restriction, which in turn is associated with increased risks of adverse health outcomes. Our prior work suggests that birthweight and childhood obesity-associated genetic variants functionally impact placental function and that placental microRNA are associated with birthweight. To address the influence of the placenta beyond birth, we assessed the relationship between placental microRNAs and early childhood gro ...[more]

PMID: 36380070

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Dataset Information

Placental microRNAs relate to early childhood growth trajectories.

Background

Methods

Results

Conclusions

Impact

Publications

Placental microRNAs relate to early childhood growth trajectories.

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