Ontology highlight
ABSTRACT:
SUBMITTER: Unali G
PROVIDER: S-EPMC10183820 | biostudies-literature | 2023 May
REPOSITORIES: biostudies-literature
Unali Giulia G Crivicich Giovanni G Pagani Isabel I Abou-Alezz Monah M Folchini Filippo F Valeri Erika E Matafora Vittoria V Reisz Julie A JA Giordano Anna Maria Sole AMS Cuccovillo Ivan I Butta Giacomo M GM Donnici Lorena L D'Alessandro Angelo A De Francesco Raffaele R Manganaro Lara L Cittaro Davide D Merelli Ivan I Petrillo Carolina C Bachi Angela A Vicenzi Elisa E Kajaste-Rudnitski Anna A
The EMBO journal 20230327 10
The interferon-induced transmembrane proteins (IFITM) are implicated in several biological processes, including antiviral defense, but their modes of action remain debated. Here, taking advantage of pseudotyped viral entry assays and replicating viruses, we uncover the requirement of host co-factors for endosomal antiviral inhibition through high-throughput proteomics and lipidomics in cellular models of IFITM restriction. Unlike plasma membrane (PM)-localized IFITM restriction that targets infe ...[more]