Ontology highlight
ABSTRACT: Introduction
Transradial access (TRA) has rapidly emerged as the preferred vascular access site for coronary angiography and percutaneous coronary intervention. Radial artery occlusion (RAO) remains as an important complication of TRA as it precludes future ipsilateral transradial procedures. While intraprocedural anticoagulation has been studied extensively, the definitive role of postprocedural anticoagulation has not yet been established.Methods and analysis
The Rivaroxaban Post-Transradial Access for the Prevention of Radial Artery Occlusion trial is a multicentre, prospective, randomised, open-label, blinded-endpoint design study investigating the efficacy and safety of rivaroxaban to reduce the incidence of RAO. Eligible patients will undergo randomisation to receive either rivaroxaban 15 mg once daily for 7 days or to no additional postprocedural anticoagulation. Doppler ultrasound to assess radial artery patency will be performed at 30 days.Ethics and dissemination
The study protocol has been approved by the Ottawa Health Science Network Research Ethics Board (approval number 20180319-01H). The study results will be disseminated via conference presentations and peer-reviewed publications.Trial registration number
NCT03630055.
SUBMITTER: Di Santo P
PROVIDER: S-EPMC10186464 | biostudies-literature | 2023 May
REPOSITORIES: biostudies-literature
Di Santo Pietro P Abdel-Razek Omar O Jung Richard R Parlow Simon S Poulin Anthony A Bernick Jordan J Morgan Baylie B Robinson Lisa L Feagan Hannah H Wade Jilliane J Goh Cheng Yee CY Singh Kuljit K Froeschl Michael M Labinaz Marino M Fergusson Dean A DA Coyle Doug D Kyeremanteng Kwadwo K Abunassar Joseph J Wells George A GA Simard Trevor T Hibbert Benjamin B
BMJ open 20230512 5
<h4>Introduction</h4>Transradial access (TRA) has rapidly emerged as the preferred vascular access site for coronary angiography and percutaneous coronary intervention. Radial artery occlusion (RAO) remains as an important complication of TRA as it precludes future ipsilateral transradial procedures. While intraprocedural anticoagulation has been studied extensively, the definitive role of postprocedural anticoagulation has not yet been established.<h4>Methods and analysis</h4>The Rivaroxaban Po ...[more]