Dataset Information

RSV, Influenza, and COVID-19 Hospitalizations in Children in Colorado During the 2021-2022 Respiratory Virus Season.

ABSTRACT:

Objective

To compare demographic characteristics, clinical features, and outcomes of children hospitalized with RSV, influenza, or SARS-CoV-2 during their co-circulation 2021-2022 respiratory virus season METHODS: We conducted a retrospective cohort study using Colorado's hospital respiratory surveillance data comparing COVID-19-, influenza-, and RSV-hospitalized cases < 18 years of age admitted and undergoing standardized molecular testing between October 1, 2021, and April 30, 2022. Multivariable log-binomial regression modeling evaluated associations between pathogen type and diagnosis, ICU admission, hospital length of stay, and highest level of respiratory support received.

Results

Among 847 hospitalized cases, 490 (57.9%) were RSV-associated, 306 (36.1%) were COVID-19-associated, and 51 (6%) were influenza-associated. Most RSV cases were <4 years of age (92.9%), whereas influenza hospitalizations were observed in older children. RSV cases were more likely to require oxygen support higher than nasal cannula compared with COVID-19 and influenza cases (p<.0001), though COVID-19 cases were more likely to require invasive mechanical ventilation than influenza and RSV cases (<.0001). Using multivariable log-binomial regression analyses, compared with children with COVID-19, the risk of ICU admission was highest among children with influenza (RR 1.97, 95% CI 1.22-3.19), whereas the risk of pneumonia, bronchiolitis, longer hospital length of stay, and need for oxygen were more likely among children with RSV.

Conclusions

In a season with respiratory pathogen co-circulation, children were hospitalized most commonly due to RSV, were younger, and required higher oxygen support and non-invasive ventilation compared with children with influenza and COVID-19.

SUBMITTER: Rao S

PROVIDER: S-EPMC10186845 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature

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Publications

Respiratory Syncytial Virus, Influenza, and Coronavirus Disease 2019 Hospitalizations in Children in Colorado During the 2021-2022 Respiratory Virus Season.

Rao Suchitra S Armistead Isaac I Tyler Amy A Lensing Madelyn M Dominguez Samuel R SR Alden Nisha B NB

The Journal of pediatrics 20230516

<h4>Objective</h4>To compare demographic characteristics, clinical features, and outcomes of children hospitalized with respiratory syncytial virus (RSV), influenza, or severe acute respiratory syndrome coronavirus 2 during their cocirculation 2021-2022 respiratory virus season.<h4>Methods</h4>We conducted a retrospective cohort study using Colorado's hospital respiratory surveillance data comparing coronavirus disease 2019 (COVID-19)-, influenza-, and RSV-hospitalized cases < 18 years of age ad ...[more]

PMID: 37201680

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