Ontology highlight
ABSTRACT:
SUBMITTER: Campbell KM
PROVIDER: S-EPMC10187051 | biostudies-literature | 2023 Apr
REPOSITORIES: biostudies-literature
Campbell Katie M KM Amouzgar Meelad M Pfeiffer Shannon M SM Howes Timothy R TR Medina Egmidio E Travers Michael M Steiner Gabriela G Weber Jeffrey S JS Wolchok Jedd D JD Larkin James J Hodi F Stephen FS Boffo Silvia S Salvador Lisa L Tenney Daniel D Tang Tracy T Thompson Marshall A MA Spencer Christine N CN Wells Daniel K DK Ribas Antoni A
Cancer cell 20230401 4
Immune checkpoint inhibitors (ICIs), including CTLA-4- and PD-1-blocking antibodies, can have profound effects on tumor immune cell infiltration that have not been consistent in biopsy series reported to date. Here, we analyze seven molecular datasets of samples from patients with advanced melanoma (N = 514) treated with ICI agents to investigate clinical, genomic, and transcriptomic features of anti-PD-1 response in cutaneous melanoma. We find that prior anti-CTLA-4 therapy is associated with d ...[more]