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A Bayesian decision-theoretic design for simultaneous biomarker-based subgroup selection and efficacy evaluation.


ABSTRACT: The success of drug development of targeted therapy often hinges on an appropriate selection of the sensitive patient population, mostly based on patients' biomarker levels. At the planning stage of a phase II study, although a potential biomarker may have been identified, a threshold value for defining sensitive patient population is often unavailable for adopting many existing biomarker-guided designs. To address this issue, we propose a two-stage design that allows for simultaneous biomarker threshold selection and efficacy evaluation while accommodating situations where the drug is efficacious in the entire patient population. The design uses a Bayesian decision-theoretic approach and incorporates the benefit and cost considerations of the study into a utility function. The operating characteristics of the proposed design under different scenarios are investigated via simulations. We also provide a discussion on the choice of the benefit and cost parameters in practice.

SUBMITTER: Wang Z 

PROVIDER: S-EPMC10187767 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature

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A Bayesian decision-theoretic design for simultaneous biomarker-based subgroup selection and efficacy evaluation.

Wang Zheyu Z   Wang Fujun F   Wang Chenguang C   Zhang Jianliang J   Wang Hao H   Shi Li L   Tang Zhuojun Z   Rosner Gary L GL  

Statistics in biopharmaceutical research 20210209 4


The success of drug development of targeted therapy often hinges on an appropriate selection of the sensitive patient population, mostly based on patients' biomarker levels. At the planning stage of a phase II study, although a potential biomarker may have been identified, a threshold value for defining sensitive patient population is often unavailable for adopting many existing biomarker-guided designs. To address this issue, we propose a two-stage design that allows for simultaneous biomarker  ...[more]

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