Ontology highlight
ABSTRACT:
SUBMITTER: Hsieh FL
PROVIDER: S-EPMC10193966 | biostudies-literature | 2023 May
REPOSITORIES: biostudies-literature
Hsieh Fu-Lien FL Chang Tao-Hsin TH Gabelli Sandra B SB Nathans Jeremy J
Proceedings of the National Academy of Sciences of the United States of America 20230508 20
Diverse extracellular proteins negatively regulate WNT signaling. One such regulator is adenomatosis polyposis coli down-regulated 1 (APCDD1), a conserved single-span transmembrane protein. In response to WNT signaling in a variety of tissues, <i>APCDD1</i> transcripts are highly up-regulated. We have determined the three-dimensional structure of the extracellular domain of APCDD1, and this structure reveals an unusual architecture consisting of two closely apposed β-barrel domains (ABD1 and ABD ...[more]