Targeting Cancer Metabolism to Improve Outcomes with Immune Checkpoint Inhibitors.
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ABSTRACT:
SUBMITTER: Fatima Z
PROVIDER: S-EPMC10195018 | biostudies-literature | 2023 May
REPOSITORIES: biostudies-literature
Publications
Targeting Cancer Metabolism to Improve Outcomes with Immune Checkpoint Inhibitors.
Fatima Zainab Z Abonofal Abdulrahman A Stephen Bettzy B
Journal of immunotherapy and precision oncology 20230202 2
Immune checkpoint inhibitors have revolutionized the treatment paradigm of several cancers. However, not all patients respond to treatment. Tumor cells reprogram metabolic pathways to facilitate growth and proliferation. This shift in metabolic pathways creates fierce competition with immune cells for nutrients in the tumor microenvironment and generates by-products harmful for immune cell differentiation and growth. In this review, we discuss these metabolic alterations and the current therapeu ...[more]
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