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ABSTRACT: Objective
We aimed at evaluating the association of maternal pre-pregnancy nutritional status with offspring anthropometry and body composition. We also evaluated whether these associations were modified by gender, diet and physical activity and mediated by birth weight.Design
Birth cohort study.Setting
Waist circumference was measured with an inextensible tape, and fat and lean mass were measured using dual-energy X-ray absorptiometry. Multiple linear regression was used to adjust for possible confounders and allele score of BMI. We carried out mediation analysis using G-formula.Participants
In 1982, 1993 and 2004, all maternity hospitals in Pelotas (South Brazil) were visited daily and all live births whose families lived in the urban area of the city were evaluated. These subjects have been followed up at different ages.Results
Offspring of obese mothers had on average higher BMI, waist circumference and fat mass index than those of normal weight mothers, and these differences were higher among daughters. The magnitudes of the association were similar in the cohorts, except for height, where the association pattern was not clear. In the 1982 cohort, further adjustment for a BMI allele score had no material influence on the magnitude of the associations. Mediation analyses showed that birth weight captured part of this association.Conclusions
Our findings suggest that maternal pre-pregnancy nutritional status is positively associated with offspring BMI and adiposity in offspring. And this association is higher among daughters whose mother was overweight or obese and, birth weight explains part of this association.
SUBMITTER: Dias MDS
PROVIDER: S-EPMC10195511 | biostudies-literature | 2021 Apr
REPOSITORIES: biostudies-literature
Dias Mariane da Silva MDS Matijasevich Alicia A Barros Aluísio Jd AJ Menezes Ana Maria B AMB Schneider Bruna Celestino BC Hartwig Fernando Pires FP Barros Fernando C FC Wehrmeister Fernando C FC Gonçalves Helen H Santos Iná S IS Assunção Maria Cecilia F MCF Horta Bernardo L BL
Public health nutrition 20201202 5
<h4>Objective</h4>We aimed at evaluating the association of maternal pre-pregnancy nutritional status with offspring anthropometry and body composition. We also evaluated whether these associations were modified by gender, diet and physical activity and mediated by birth weight.<h4>Design</h4>Birth cohort study.<h4>Setting</h4>Waist circumference was measured with an inextensible tape, and fat and lean mass were measured using dual-energy X-ray absorptiometry. Multiple linear regression was used ...[more]