Ontology highlight
ABSTRACT:
SUBMITTER: Reid P
PROVIDER: S-EPMC10198805 | biostudies-literature | 2022 Dec
REPOSITORIES: biostudies-literature
Reid Pankti P Cappelli Laura C LC
Best practice & research. Clinical rheumatology 20221218 4
Immune checkpoint inhibitors (ICIs), used to treat many advanced cancers, activate the immune system to elicit an antitumor response. ICIs can also cause immune-related adverse events (irAEs) when nontumor tissues are affected by excess inflammation and autoimmunity. Rheumatic irAEs include inflammatory arthritis, myositis, sicca syndrome, polymyalgia rheumatica, and several other rare phenotypes. Treating rheumatic irAEs requires balancing the desire to decrease off-target inflammation while no ...[more]