Dataset Information

Association between base excess and 28-day mortality in sepsis patients: A secondary analysis based on the MIMIC- IV database.

ABSTRACT:

Objective

The relationship between base excess (BE) and 28-day death in sepsis patients remains to be elucidated. The aim of our clinical study is to explore the association of BE with 28-day mortality in patients with sepsis by using a large sample, multicenter Medical Information Mart for Intensive Care IV (MIMIC-IV) database.

Methods

We extracted the data of 35,010 patients with sepsis from the MIMIC-IV database, in which we used BE as an exposure variable and the 28-day mortality as an outcome variable, respectively, so as to explore the impact of BE on the 28-day mortality of patients with sepsis after adjusting for covariates.

Results

BE and the 28-day mortality of patients with sepsis appeared to have a U-shaped relationship. The calculated inflection points were -2.5 mEq/L and 1.9 mEq/L, respectively. Our data demonstrated that BE was negatively associated with 28-day mortality in the range of -41.0 mEq/L to -2.5 mEq/L (odds ratio: 0.95; 95% confidence intervals (95%CI): 0.93 to 0.96), p < 0.0001. When BE was in the range of 1.9 mEq/L to 55.5 mEq/L, however, a positive association existed between BE and 28-day mortality of patients with sepsis (odds ratio: 1.03; 95% CI: 1.00 to 1.05; p < 0.05).

Conclusion

The BE levels have a U-shaped relationship with the 28-day mortality in patients with sepsis, in which the mortality of patients will gradually decrease with a BE value from -41.0 mEq/L to -2.5 mEq/L, while the mortality will increase with a BE value from 1.9 mEq/L to 55.5 mEq/L.

SUBMITTER: Yuan J

PROVIDER: S-EPMC10199177 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature

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Publications

Association between base excess and 28-day mortality in sepsis patients: A secondary analysis based on the MIMIC- IV database.

Yuan Jia J Liu Xu X Liu Ying Y Li Wei W Chen Xianjun X Chen Qiming Q Xiao Chuan C Wan Ying Y Li Shuwen S Li Qing Q Li Lu L He Juan J Chen Lu L Shen Feng F

Heliyon 20230509 5

<h4>Objective</h4>The relationship between base excess (BE) and 28-day death in sepsis patients remains to be elucidated. The aim of our clinical study is to explore the association of BE with 28-day mortality in patients with sepsis by using a large sample, multicenter Medical Information Mart for Intensive Care IV (MIMIC-IV) database.<h4>Methods</h4>We extracted the data of 35,010 patients with sepsis from the MIMIC-IV database, in which we used BE as an exposure variable and the 28-day mortal ...[more]

PMID: 37215834

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Dataset Information

Association between base excess and 28-day mortality in sepsis patients: A secondary analysis based on the MIMIC- IV database.

Objective

Methods

Results

Conclusion

Publications

Association between base excess and 28-day mortality in sepsis patients: A secondary analysis based on the MIMIC- IV database.

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