Dataset Information

Relationship between gestational acrylamide exposure and offspring's growth: a systematic review and meta-analysis of cohort studies.

ABSTRACT:

Objective

To estimate the current evidence regarding the association between gestational acrylamide (AA) exposure and offspring's growth.

Design

Systematic review and meta-analysis.

Setting

A systematic literature search for relevant publications was conducted using PubMed, Medline, Embase, Web of Science databases from inception to 26 April 2019. The standardised mean difference (SMD) or OR with 95 % CI was selected as the effect sizes and was calculated using a random effects model.

Results

Five cohort studies including 54 728 participants were identified. Offspring's birth weight was significantly lower in high AA exposure group than in low AA exposure group (SMD -0·05, 95 % CI -0·09, -0·02, P = 0·005). There was also an association between maternal AA exposure and small for gestational age (OR 1·14, 95 % CI 1·06, 1·23, P < 0·001). In addition, pooled ORs suggested that children had a high risk of developing overweight/obesity in the future in maternal high AA exposure group (OR 1·14, 95 % CI 1·08, 1·21, P < 0·001 at age 3; OR 1·13, 95 % CI 1·07, 1·19, P < 0·001 at age 5; OR 1·09, 95 % CI 1·02, 1·16, P = 0·020 at age 8).

Conclusions

These findings have important implications for conducting health education, providing guidance on maternal diet and developing an appropriate dietary strategy for pregnant women to reduce dietary AA exposure.

SUBMITTER: Zhan Y

PROVIDER: S-EPMC10200512 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Relationship between gestational acrylamide exposure and offspring's growth: a systematic review and meta-analysis of cohort studies.

Zhan Yongle Y Xiao Ying Y Guan Tianjia T Zhang Shuyang S Jiang Yu Y

Public health nutrition 20200430 10

<h4>Objective</h4>To estimate the current evidence regarding the association between gestational acrylamide (AA) exposure and offspring's growth.<h4>Design</h4>Systematic review and meta-analysis.<h4>Setting</h4>A systematic literature search for relevant publications was conducted using PubMed, Medline, Embase, Web of Science databases from inception to 26 April 2019. The standardised mean difference (SMD) or OR with 95 % CI was selected as the effect sizes and was calculated using a random eff ...[more]

PMID: 32349855

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Project description:ObjectiveHyperglycaemia during pregnancy is associated with cardiometabolic risks for the mother and the offspring. Mothers with gestational diabetes mellitus (GDM) have signs of subclinical atherosclerosis, including increased carotid intima-media thickness (CIMT). We assessed whether GDM is associated with increased CIMT in the offspring at birth.Design and settingMySweetHeart Cohort is a prospective cohort study conducted in Switzerland.Participants, exposure and outcome measuresThis work included pregnant women with and without GDM at 24-32 weeks of gestation and their singleton live-born offspring with data on the primary outcome of CIMT. GDM was diagnosed based on the criteria of the International Association of Diabetes and Pregnancy Study Groups. Offspring's CIMT was measured by ultrasonography after birth (range 1-19 days).ResultsData on CIMT were available for 99 offspring of women without GDM and 101 offspring of women with GDM. Maternal age ranged from 18 to 47 years. Some 16% of women with GDM and 6% of women without GDM were obese. Smoking during pregnancy was more frequent among women with GDM (18%) than among those without GDM (4%). Neonatal characteristics were comparable between the two groups. The difference in CIMT between offspring of women with and without GDM was of 0.00 mm (95% CI -0.01 to 0.01; p=0.96) and remained similar on adjustment for potential confounding factors, such as maternal prepregnancy body mass index, maternal education, smoking during pregnancy, family history of diabetes, as well as offspring's sex, age, and body surface area (0.00 mm (95% CI -0.02 to 0.01; p=0.45)).ConclusionsWe found no evidence of increased CIMT in neonates exposed to GDM. A longer-term follow-up that includes additional vascular measures, such as endothelial function or arterial stiffness, may shed further light on the cardiovascular health trajectories in children born to mothers with GDM.Trial registration numberNCT02872974; Pre-results.

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Dataset Information

Relationship between gestational acrylamide exposure and offspring's growth: a systematic review and meta-analysis of cohort studies.

Objective

Design

Setting

Results

Conclusions

Publications

Relationship between gestational acrylamide exposure and offspring's growth: a systematic review and meta-analysis of cohort studies.

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