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Detection of Leishmania RNA Virus 1 in Leishmania (Viannia) panamensis Isolates, Panama.

ABSTRACT: We detected Leishmania RNA virus 1 (LRV1) in 11 isolates of Leishmania (Viannia) panamensis collected during 2014-2019 from patients from different geographic areas in Panama. The distribution suggested a spread of LRV1 in L. (V.) panamensis parasites. We found no association between LRV1 and an increase in clinical pathology.

SUBMITTER: Gonzalez K

PROVIDER: S-EPMC10202884 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature

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Detection of Leishmania RNA Virus 1 in Leishmania (Viannia) panamensis Isolates, Panama.

Gonzalez Kadir K De León Santiago S SS Pineda Vanessa V Samudio Franklyn F Capitan-Barrios Zeuz Z Suarez José Antonio JA Weeden Adriana A Ortiz Betsi B Rios Margarita M Moreno Brechla B Gundacker Nathan D ND Pascale Juan M JM López-Vergès Sandra S Sosa Néstor N Saldaña Azael A Ábrego Leyda E LE

Emerging infectious diseases 20230601 6

We detected Leishmania RNA virus 1 (LRV1) in 11 isolates of Leishmania (Viannia) panamensis collected during 2014-2019 from patients from different geographic areas in Panama. The distribution suggested a spread of LRV1 in L. (V.) panamensis parasites. We found no association between LRV1 and an increase in clinical pathology. ...[more]

PMID: 37209675

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Insights into the Genetic Diversity of Leishmania (Viannia) panamensis in Panama, Inferred via Multilocus Sequence Typing (MLST).

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Project description:Kinetoplastid parasites of the Leishmania genus cause several forms of leishmaniasis. Leishmania species pathogenic to human are separated into two subgenera, Leishmania (Leishmania) and L. (Viannia). Species from the Viannia subgenus cause predominantly cutaneous leishmaniasis in Central and South America, occasionally leading to more severe clinical presentations. Although the genomes of several species of Leishmania have been sequenced to date, only one belongs to this rather different subgenus. Here we explore the unique features of the Viannia subgenus by sequencing and analyzing the genome of L. (Viannia) panamensis. Against a background of conservation in gene content and synteny, we found key differences at the genomic level that may explain the occurrence of molecular processes involving nucleic acid manipulation and differential modification of surface glycoconjugates. These differences may in part explain some phenotypic characteristics of the Viannia parasites, including their increased adaptive capacity and enhanced metastatic ability.

| S-EPMC4338418 | biostudies-literature

Human Macrophage Response to Leishmania (Viannia) panamensis Infection: Evidence for an Early Inflammatory Response

Project description:Transcriptional profile of human monocyte-derived macrophages infected with L.(V.)panamensis was compared to the profile of uninfected cells to delineate transcriptional activation triggered by the infection.

2012-12-25 | GSE25819 | GEO

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