Ontology highlight
ABSTRACT:
SUBMITTER: Webb BL
PROVIDER: S-EPMC102184 | biostudies-literature | 2000 Dec
REPOSITORIES: biostudies-literature
Webb B L BL Jimenez E E Martin G S GS
Molecular and cellular biology 20001201 24
Evasion of apoptosis appears to be a necessary event in tumor progression. Some oncogenes, such as c-myc and E1A, induce apoptosis in the absence of survival factors. However, others, such as bcl-2 and v-src, activate antiapoptotic pathways. For v-Src, these antiapoptotic pathways are dependent on the function of Ras, phosphatidylinositol (PI) 3-kinase, and Stat3. Here we asked whether v-Src can activate a proapoptotic signal when survival signaling is inhibited. We show that when the functions ...[more]