Ontology highlight
ABSTRACT:
SUBMITTER: Ding S
PROVIDER: S-EPMC10220648 | biostudies-literature | 2023 May
REPOSITORIES: biostudies-literature
Ding Shilei S Tolbert William D WD Zhu Huile H Lee Daniel D Marchitto Lorie L Higgins Tyler T Zhao Xuchen X Nguyen Dung D Sherburn Rebekah R Richard Jonathan J Gendron-Lepage Gabrielle G Medjahed Halima H Mohammadi Mohammadjavad M Abrams Cameron C Pazgier Marzena M Smith Amos B AB Finzi Andrés A
Viruses 20230517 5
The ability of the HIV-1 accessory proteins Nef and Vpu to decrease CD4 levels contributes to the protection of infected cells from antibody-dependent cellular cytotoxicity (ADCC) by preventing the exposure of Env vulnerable epitopes. Small-molecule CD4 mimetics (CD4mc) based on the indane and piperidine scaffolds such as (+)-BNM-III-170 and (<i>S</i>)-MCG-IV-210 sensitize HIV-1-infected cells to ADCC by exposing CD4-induced (CD4i) epitopes recognized by non-neutralizing antibodies that are abun ...[more]