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ABSTRACT: Introduction
There is negligible evidence on the efficacy of ivermectin for treating COVID-19 pneumonia. This study aimed to assess the efficacy of ivermectin for pre-emptively treating Strongyloides stercoralis hyperinfection syndrome in order to reduce mortality and the need for respiratory support in patients hospitalized for COVID-19.Methods
This single-center, observational, retrospective study included patients admitted with COVID-19 pneumonia at Hospital Vega Baja from 23 February 2020 to 14 March 2021. Because strongyloidiasis is endemic to our area, medical criteria support empiric administration of a single, 200 μg/kg dose of ivermectin to prevent Strongyloides hyperinfection syndrome. The outcome was a composite of all-cause in-hospital mortality and the need for respiratory support.Results
Of 1167 patients in the cohort, 96 received ivermectin. After propensity score matching, we included 192 patients. The composite outcome of in-hospital mortality or need for respiratory support occurred in 41.7% of the control group (40/96) and 34.4% (33/96) of the ivermectin group. Ivermectin was not associated with the outcome of interest (adjusted odds ratio [aOR] 0.77, 95% confidence interval [CI] 0.35, 1.69; p = 0.52). The factors independently associated with this endpoint were oxygen saturation (aOR 0.78, 95% CI 0.68, 0.89, p < 0.001) and C-reactive protein at admission (aOR: 1.09, 95% CI 1.03, 1.16, p < 0.001).Conclusions
In hospitalized patients with COVID-19 pneumonia, ivermectin at a single dose for pre-emptively treating Strongyloides stercoralis is not effective in reducing mortality or the need for respiratory support measures.
SUBMITTER: Llenas-Garcia J
PROVIDER: S-EPMC10222278 | biostudies-literature | 2023 May
REPOSITORIES: biostudies-literature
Llenas-García Jara J Del Pozo Alfonso A Talaya Alberto A Roig-Sánchez Nuria N Poveda Ruiz Noemí N Devesa García Carlos C Borrajo Brunete Emilio E González Cuello Inmaculada I Lucas Dato Ana A Navarro Miriam M Wikman-Jorgensen Philip P
Viruses 20230510 5
<h4>Introduction</h4>There is negligible evidence on the efficacy of ivermectin for treating COVID-19 pneumonia. This study aimed to assess the efficacy of ivermectin for pre-emptively treating <i>Strongyloides stercoralis</i> hyperinfection syndrome in order to reduce mortality and the need for respiratory support in patients hospitalized for COVID-19.<h4>Methods</h4>This single-center, observational, retrospective study included patients admitted with COVID-19 pneumonia at Hospital Vega Baja f ...[more]