Ontology highlight
ABSTRACT:
SUBMITTER: Fan Y
PROVIDER: S-EPMC10222606 | biostudies-literature | 2023 Apr
REPOSITORIES: biostudies-literature
Fan Yongfeng Y Lou Jianlong J Tam Christina C CC Wen Weihua W Conrad Fraser F Leal da Silva Alves Priscila P Cheng Luisa W LW Garcia-Rodriguez Consuelo C Farr-Jones Shauna S Marks James D JD
Toxins 20230430 5
Equine-derived antitoxin (BAT<sup>®</sup>) is the only treatment for botulism from botulinum neurotoxin serotype G (BoNT/G). BAT<sup>®</sup> is a foreign protein with potentially severe adverse effects and is not renewable. To develop a safe, more potent, and renewable antitoxin, humanized monoclonal antibodies (mAbs) were generated. Yeast displayed single chain Fv (scFv) libraries were prepared from mice immunized with BoNT/G and BoNT/G domains and screened with BoNT/G using fluorescence-activa ...[more]