Ontology highlight
ABSTRACT:
SUBMITTER: Nakagawa T
PROVIDER: S-EPMC10224979 | biostudies-literature | 2023 May
REPOSITORIES: biostudies-literature
Nakagawa Tatsuya T Tokuda Yuichi Y Nakano Masakazu M Komori Yuya Y Hanada Naoya N Tourtas Theofilos T Schlötzer-Schrehardt Ursula U Kruse Friedrich F Tashiro Kei K Koizumi Noriko N Okumura Naoki N
Scientific reports 20230527 1
Fuchs endothelial corneal dystrophy (FECD) is the most common inherited corneal disease. Fibrillar focal excrescences called guttae and corneal edema due to corneal endothelial cell death result in progressive vision loss. Multiple genetic variants have been reported, but the pathogenesis of FECD is not fully understood. In this study, we used RNA-Seq to analyze differential gene expression in the corneal endothelium obtained from patients with FECD. Differential expression analysis of transcrip ...[more]