Dataset Information
Association between leukocyte telomere length and COVID-19 severity.
Ontology highlight
ABSTRACT: Background
Inter-individual variations in the clinical manifestations of SARS-CoV-2 infection are among the challenging features of COVID-19. The known role of telomeres in cell proliferation and immune competency highlights their possible function in infectious diseases. Variability in telomere length is an invaluable parameter in the heterogeneity of the clinical presentation of diseases.Result
In this study, our aim was to investigate the possible association between leukocyte telomere length (LTL) and COVID-19 severity. LTL was measured in 100 patients with moderate and severe forms of COVID-19 using the quantitative PCR (q-PCR) method. Statistical analysis confirmed a strong inverse correlation between relative LTL and COVID-19 severity.Conclusions
These findings suggest that LTL can be a useful parameter for predicting disease severity in patients, as individuals with short telomeres may have a higher risk of developing severe COVID-19.Supplementary information
The online version contains supplementary material available at 10.1186/s43042-023-00415-z.
SUBMITTER: Mahmoodpoor A
PROVIDER: S-EPMC10225776 | biostudies-literature | 2023
REPOSITORIES: biostudies-literature
Publications
Association between leukocyte telomere length and COVID-19 severity.
The Egyptian journal of medical human genetics 20230529 1
<h4>Background</h4>Inter-individual variations in the clinical manifestations of SARS-CoV-2 infection are among the challenging features of COVID-19. The known role of telomeres in cell proliferation and immune competency highlights their possible function in infectious diseases. Variability in telomere length is an invaluable parameter in the heterogeneity of the clinical presentation of diseases.<h4>Result</h4>In this study, our aim was to investigate the possible association between leukocyte ...[more]