Risk stratified monitoring for methotrexate toxicity in immune mediated inflammatory diseases: prognostic model development and validation using primary care data from the UK.

ABSTRACT:

Objective

To develop and validate a prognostic model to inform risk stratified decisions on frequency of monitoring blood tests during long term methotrexate treatment.

Design

Retrospective cohort study.

Setting

Electronic health records within the UK's Clinical Practice Research Datalink (CPRD) Gold and CPRD Aurum.

Participants

Adults (≥18 years) with a diagnosis of an immune mediated inflammatory disease who were prescribed methotrexate by their general practitioner for six months or more during 2007-19.

Main outcome measure

Discontinuation of methotrexate owing to abnormal monitoring blood test result. Patients were followed-up from six months after their first prescription for methotrexate in primary care to the earliest of outcome, drug discontinuat

SUBMITTER: Nakafero G 

PROVIDER: S-EPMC10227711 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature