Dataset Information

Trends in kidney transplantation rate across Europe: study from the ERA Registry.

ABSTRACT:

Background

The aim of this study was to identify trends in total, deceased donor (DD) and living donor (LD) kidney transplantation (KT) rates in European countries.

Methods

The European Renal Association (ERA) Registry and the Global Observatory on Donation and Transplantation (GODT) databases were used to obtain the number of KTs in individual European countries between 2010 and 2018. General population counts were obtained from Eurostat or the national bureaus of statistics. The KT rate per million population (p.m.p.) and the average annual percentage change (APC) were calculated.

Results

The total KT rate in the 40 participating countries increased with 1.9% annually [95% confidence interval (CI) 1.5, 2.2] from 29.6 p.m.p. in 2010 to 34.7 p.m.p. in 2018, reflecting an increase of 3.4 p.m.p. in the DD-KT rate (from 21.6 p.m.p. to 25.0 p.m.p.; APC 1.9%; 95% CI 1.3, 2.4) and of 1.5 p.m.p. in the LD-KT rate (from 8.1 p.m.p. to 9.6 p.m.p.; APC 1.6%; 95% CI 1.0, 2.3). The trends in KT rate varied widely across European countries. An East-West gradient was observed for DD-KT rate, with Western European countries performing more KTs. In addition, most countries performed fewer LD-KTs. In 2018, Spain had the highest DD-KT rate (64.6 p.m.p.) and Turkey the highest LD-KT rate (37.0 p.m.p.).

Conclusions

The total KT rate increased due to a rise in the KT rate from DDs and to a lesser extent from LDs, with large differences between individual European countries.

SUBMITTER: Boenink R

PROVIDER: S-EPMC10229282 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Trends in kidney transplantation rate across Europe: study from the ERA Registry.

Boenink Rianne R Kramer Anneke A Tuinhout Rosalie E RE Savoye Emilie E Åsberg Anders A Idrizi Alma A Kerschbaum Julia J Ziedina Ieva I Ziginskiene Edita E Farrugia Emanuel E Garneata Liliana L Zakharova Elena V EV Bell Samira S Arnol Miha M Segelmark Mårten M Ioannou Kyriakos K Hommel Kristine K Rosenberg-Ots Mai M Vazelov Evgueniy E Helve Jaakko J Mihály Sándor S Pálsson Runólfur R Nordio Maurizio M Gjorgjievski Nikola N de Vries Aiko P J APJ Seyahi Nurhan N Magadi Winnie A WA Resić Halima H Kalachyk Aleh A Rahmel Axel O AO Galvão Ana A AA Naumovic Radomir R Lundgren Torbjörn T Arici Mustafa M de Meester Johan M JM Ortiz Alberto A Jager Kitty J KJ Stel Vianda S VS

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20230501 6

<h4>Background</h4>The aim of this study was to identify trends in total, deceased donor (DD) and living donor (LD) kidney transplantation (KT) rates in European countries.<h4>Methods</h4>The European Renal Association (ERA) Registry and the Global Observatory on Donation and Transplantation (GODT) databases were used to obtain the number of KTs in individual European countries between 2010 and 2018. General population counts were obtained from Eurostat or the national bureaus of statistics. The ...[more]

PMID: 36610723

Similar Datasets

Project description:BackgroundIn 2020, the coronavirus disease 2019 (COVID-19) pandemic caused disruptions in kidney replacement therapy (KRT) services worldwide. The aim of this study was to assess the effect of the COVID-19 pandemic in 2020 on the incidence of KRT, kidney transplantation activity, mortality and prevalence of KRT across Europe.MethodsPatients receiving KRT were included from 17 countries providing data to the European Renal Association Registry. The epidemiology of KRT in 2020 was compared with average data from the period 2017-2019. Changes occurring during the first and second waves of the pandemic were also explored.ResultsThe incidence of KRT was 6.2% lower in 2020 compared with 2017-2019, with the lowest point (-22.7%) during the first wave in April. The decrease varied across countries, was smaller in males (-5.2%) than in females (-8.2%) and was moderate for peritoneal dialysis (-3.7%) and haemodialysis (-5.4%) but substantial for pre-emptive kidney transplantation (-23.6%). The kidney transplantation rate decreased by 22.5%, reaching a nadir of -80.1% during the first wave, and was greatest for living donor kidney transplants (-30.5%). While in most countries the kidney transplantation rate decreased, in the Nordic/Baltic countries and Greece there was no clear decrease. In dialysis patients, mortality increased by 11.4% and was highest in those 65-74 years of age (16.1%), in those with diabetes as the primary renal disease (15.1%) and in those on haemodialysis (12.4%). In transplant recipients, the mortality was 25.8% higher, but there were no subgroups that stood out. In contrast to the rising prevalence of KRT observed over the past decades across Europe, the prevalence at the end of 2020 (N = 317 787) resembled that of 2019 (N = 317 077).ConclusionThe COVID-19 pandemic has had a substantial impact on the incidence of KRT, kidney transplant activity, mortality of KRT and prevalence of KRT in Europe with variations across countries.

Dataset Information

Trends in kidney transplantation rate across Europe: study from the ERA Registry.

Background

Methods

Results

Conclusions

Publications

Trends in kidney transplantation rate across Europe: study from the ERA Registry.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets