Dataset Information

Dynamic contrast-enhanced computed tomography in dogs with nasal tumors.

ABSTRACT:

Background

Treatment of nasal tumors in dogs is associated with high morbidity and reliable prognostic factors are lacking. Dynamic contrast-enhanced computed tomography (DCECT) can be used to assess tumor perfusion.

Objectives

To assess perfusion parameters of nasal tumors (correlating with tumor type) before and during radiotherapy (RT) and find potential correlation with survival.

Animals

Twenty-four client-owned dogs with nasal tumors, including 16 epithelial tumors and 8 sarcomas.

Methods

Prospective cross-sectional study. All dogs had baseline DCECT to assess fractional vascular volume (BV), blood flow (BF), and transit time (TT). Thirteen dogs had repeat DCECT after 12 Gy of megavoltage RT. Survival times were calculated.

Results

Median BV was 17.83 mL/100 g (range, 3.63-66.02), median BF was 122.63 mL/100 g/minute (range, 23.65-279.99), and median TT was 8.91 seconds (range, 4.57-14.23). Sarcomas had a significantly lower BF than adenocarcinomas (P = .002), carcinomas (P = .01), and other carcinomas (P = .001), and significantly lower BV than adenocarcinomas (P = .03) and other carcinomas (P = .004). Significant associations were found between epithelial tumors and sarcoma for change in tumor volume (P = .01), width (P = .004), and length (P = .02) in that epithelial tumors decreased in volume whereas sarcomas increased in volume. Perfusion parameters were not correlated with survival.

Conclusions and clinical importance

Nasal sarcomas have lower BV and BF than nasal carcinomas, and sarcomas have a lower size reduction than carcinomas early on during RT. Baseline results and changes in perfusion parameters may not be correlated with survival.

SUBMITTER: Mortier JR

PROVIDER: S-EPMC10229329 | biostudies-literature | 2023 May-Jun

REPOSITORIES: biostudies-literature

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Publications

Dynamic contrast-enhanced computed tomography in dogs with nasal tumors.

Mortier Jeremy R JR Maddox Thomas W TW Blackwood Laura L La Fontaine Matthew D MD Busoni Valeria V

Journal of veterinary internal medicine 20230424 3

<h4>Background</h4>Treatment of nasal tumors in dogs is associated with high morbidity and reliable prognostic factors are lacking. Dynamic contrast-enhanced computed tomography (DCECT) can be used to assess tumor perfusion.<h4>Objectives</h4>To assess perfusion parameters of nasal tumors (correlating with tumor type) before and during radiotherapy (RT) and find potential correlation with survival.<h4>Animals</h4>Twenty-four client-owned dogs with nasal tumors, including 16 epithelial tumors and ...[more]

PMID: 37092693

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Dataset Information

Dynamic contrast-enhanced computed tomography in dogs with nasal tumors.

Background

Objectives

Animals

Methods

Results

Conclusions and clinical importance

Publications

Dynamic contrast-enhanced computed tomography in dogs with nasal tumors.

Similar Datasets

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