Dataset Information

Mineral, trace element, and toxic metal concentration in hair from dogs with idiopathic epilepsy compared to healthy controls.

ABSTRACT:

Background

Altered trace element status is associated with epilepsy in humans and dogs with idiopathic epilepsy (IE).

Objectives

Compare hair element concentrations in epileptic and healthy dogs.

Animals

Sixty-three dogs with IE (53 treated, 10 untreated) and 42 controls.

Methods

Case-control study using ICP-MS to determine hair calcium, magnesium, phosphorus, sodium, potassium, iron, copper, manganese, zinc, selenium, chromium, lead, mercury, cadmium, arsenic, aluminum, and nickel concentration. Groups were compared using nonparametric tests. Results were controlled for diet, sex, age, and hair color using generalized linear mixed models.

Results

Compared to healthy controls, dogs with IE had lower hair phosphorus (mean ± SD; IE: 286.19 ± 69.62 μg/g, healthy: 324.52 ± 58.69 μg/g; P = .001), higher hair copper (IE: 10.97 ± 3.51 μg/g, healthy: 8.41 ± 1.27 μg/g; P < .001), zinc (IE: 158.25 ± 19.64 μg/g, healthy: 144.76 ± 32.18 μg/g; P < .001), copper/zinc ratio (IE: 0.07 ± 0.02, healthy: 0.06 ± 0.01; P = .003), selenium (IE: 1.65 ± 0.43 μg/g, healthy: 0.94 ± 0.73 μg/g; P < .001), and arsenic (IE: 0.40 ± 0.78 μg/g, healthy: 0.05 ± 0.08 μg/g; P < .001). When comparing treated and untreated epileptic dogs with healthy dogs, the differences in phosphorus and selenium remained significant for both groups, whereas the differences in copper, zinc, and arsenic were significant only for treated dogs. Potassium bromide treatment was strongly associated with high hair arsenic (P = .000).

Conclusions and clinical importance

Altered trace element status could be involved in the pathophysiology of IE in dogs. Antiseizure drugs might affect trace element and arsenic metabolism.

SUBMITTER: Rosendahl S

PROVIDER: S-EPMC10229330 | biostudies-literature | 2023 May-Jun

REPOSITORIES: biostudies-literature

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Publications

Mineral, trace element, and toxic metal concentration in hair from dogs with idiopathic epilepsy compared to healthy controls.

Rosendahl Sarah S Anturaniemi Johanna J Kukko-Lukjanov Tiina-Kaisa TK Vuori Kristiina A KA Moore Robin R Hemida Manal M Muhle Anne A Hielm-Björkman Anna A

Journal of veterinary internal medicine 20230406 3

<h4>Background</h4>Altered trace element status is associated with epilepsy in humans and dogs with idiopathic epilepsy (IE).<h4>Objectives</h4>Compare hair element concentrations in epileptic and healthy dogs.<h4>Animals</h4>Sixty-three dogs with IE (53 treated, 10 untreated) and 42 controls.<h4>Methods</h4>Case-control study using ICP-MS to determine hair calcium, magnesium, phosphorus, sodium, potassium, iron, copper, manganese, zinc, selenium, chromium, lead, mercury, cadmium, arsenic, alumi ...[more]

PMID: 37025060

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Dataset Information

Mineral, trace element, and toxic metal concentration in hair from dogs with idiopathic epilepsy compared to healthy controls.

Background

Objectives

Animals

Methods

Results

Conclusions and clinical importance

Publications

Mineral, trace element, and toxic metal concentration in hair from dogs with idiopathic epilepsy compared to healthy controls.

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