Ontology highlight
ABSTRACT:
SUBMITTER: Hsu PC
PROVIDER: S-EPMC10240213 | biostudies-literature | 2023 Jun
REPOSITORIES: biostudies-literature
Hsu Po-Chen PC Cheng Yu-Hsuan YH Liao Chia-Wei CW Litan Richard Ron R RRR Jhou Yu-Ting YT Opoc Florica Jean Ganaden FJG Amine Ahmed A A AAA Leu Jun-Yi JY
EMBO reports 20230403 6
The discrete steps of transcriptional rewiring have been proposed to occur neutrally to ensure steady gene expression under stabilizing selection. A conflict-free switch of a regulon between regulators may require an immediate compensatory evolution to minimize deleterious effects. Here, we perform an evolutionary repair experiment on the Lachancea kluyveri yeast sef1Δ mutant using a suppressor development strategy. Complete loss of SEF1 forces cells to initiate a compensatory process for the pl ...[more]