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Interaction between Peripheral and Central immune markers in Clinical High Risk for Psychosis.


ABSTRACT: •Serum IL-8 levels are elevated in individuals at CHR for psychosis.•Positive association between elevated IL-8 and prodromal general symptom severity.•Inflammatory clusters (IL-1β, IL-2, IFN-γ) are identified (entire cohort and CHR).•TSPO levels did not differ between inflammatory clusters (entire cohort or CHR).•CRP, IL-1β, TNF-α and IFN-γ levels are the independent predictors of brain TSPO.

SUBMITTER: Nisha Aji K 

PROVIDER: S-EPMC10244662 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature

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Interaction between peripheral and central immune markers in clinical high risk for psychosis.

Nisha Aji Kankana K   Hafizi Sina S   Da Silva Tania T   Kiang Michael M   Rusjan Pablo M PM   Weickert Cynthia Shannon CS   Mizrahi Romina R  

Brain, behavior, & immunity - health 20230513


Neuroinflammatory events prior to the diagnosis of schizophrenia may play a role in transition to illness. To date only one <i>in-vivo</i> study has investigated this association between peripheral proinflammatory cytokines and brain markers of inflammation (e.g., mitochondrial 18 kDa translocator protein, TSPO) in schizophrenia, but none in its putative prodrome. In this study, we primarily aimed to (Barron et al., 2017) test study group (clinical high-risk (CHR) and healthy controls) differenc  ...[more]

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