Ontology highlight
ABSTRACT:
SUBMITTER: Jonas F
PROVIDER: S-EPMC10250222 | biostudies-literature | 2023 Jun
REPOSITORIES: biostudies-literature
Jonas Felix F Carmi Miri M Krupkin Beniamin B Steinberger Joseph J Brodsky Sagie S Jana Tamar T Barkai Naama N
Nucleic acids research 20230601 10
Intrinsically disordered regions (IDRs) direct transcription factors (TFs) towards selected genomic occurrences of their binding motif, as exemplified by budding yeast's Msn2. However, the sequence basis of IDR-directed TF binding selectivity remains unknown. To reveal this sequence grammar, we analyze the genomic localizations of >100 designed IDR mutants, each carrying up to 122 mutations within this 567-AA region. Our data points at multivalent interactions, carried by hydrophobic-mostly alip ...[more]