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Emerging Targeted Therapies in Advanced Non-Small-Cell Lung Cancer.

ABSTRACT: Lung cancer remains the leading cause of cancer-related mortality worldwide. Non-small-cell lung cancer (NSCLC) is the most common type and is still incurable for most patients at the advanced stage. Targeted therapy is an effective treatment that has significantly improved survival in NSCLC patients with actionable mutations. However, therapy resistance occurs widely among patients leading to disease progression. In addition, many oncogenic driver mutations in NSCLC still lack targeted agents. New drugs are being developed and tested in clinical trials to overcome these challenges. This review aims to summarize emerging targeted therapy that have been conducted or initiated through first-in-human clinical trials in the past year.

SUBMITTER: Li S

PROVIDER: S-EPMC10251928 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature

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Emerging Targeted Therapies in Advanced Non-Small-Cell Lung Cancer.

Li Shenduo S de Camargo Correia Guilherme Sacchi GS Wang Jing J Manochakian Rami R Zhao Yujie Y Lou Yanyan Y

Cancers 20230524 11

Lung cancer remains the leading cause of cancer-related mortality worldwide. Non-small-cell lung cancer (NSCLC) is the most common type and is still incurable for most patients at the advanced stage. Targeted therapy is an effective treatment that has significantly improved survival in NSCLC patients with actionable mutations. However, therapy resistance occurs widely among patients leading to disease progression. In addition, many oncogenic driver mutations in NSCLC still lack targeted agents. ...[more]

PMID: 37296863

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