Sequence variants affecting voice pitch in humans.
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ABSTRACT:
SUBMITTER: Gisladottir RS
PROVIDER: S-EPMC10256171 | biostudies-literature | 2023 Jun
REPOSITORIES: biostudies-literature
Publications
Sequence variants affecting voice pitch in humans.
Gisladottir Rosa S RS Helgason Agnar A Halldorsson Bjarni V BV Helgason Hannes H Borsky Michal M Chien Yu-Ren YR Gudnason Jon J Gudjonsson Sigurjon A SA Moisik Scott S Dediu Dan D Thorleifsson Gudmar G Tragante Vinicius V Bustamante Mariana M Jonsdottir Gudrun A GA Stefansdottir Lilja L Rutsdottir Gudrun G Magnusson Sigurdur H SH Hardarson Marteinn M Ferkingstad Egil E Halldorsson Gisli H GH Rognvaldsson Solvi S Skuladottir Astros A Ivarsdottir Erna V EV Norddahl Gudmundur G Thorgeirsson Gudmundur G Jonsdottir Ingileif I Ulfarsson Magnus O MO Holm Hilma H Stefansson Hreinn H Thorsteinsdottir Unnur U Gudbjartsson Daniel F DF Sulem Patrick P Stefansson Kari K
Science advances 20230609 23
The genetic basis of the human vocal system is largely unknown, as are the sequence variants that give rise to individual differences in voice and speech. Here, we couple data on diversity in the sequence of the genome with voice and vowel acoustics in speech recordings from 12,901 Icelanders. We show how voice pitch and vowel acoustics vary across the life span and correlate with anthropometric, physiological, and cognitive traits. We found that voice pitch and vowel acoustics have a heritable ...[more]
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