Dataset Information

Vitamin D intake and risk of CVD and all-cause mortality: evidence from the Caerphilly Prospective Cohort Study.

ABSTRACT:

Objective

Prospective data on the associations between vitamin D intake and risk of CVD and all-cause mortality are limited and inconclusive. The aim of the present study was to investigate the associations between vitamin D intake and CVD risk and all-cause mortality in the Caerphilly Prospective Cohort Study.

Design

The associations of vitamin D intake with CVD risk markers were examined cross-sectionally at baseline and longitudinally at 5-year, 10-year and >20-year follow-ups. In addition, the predictive value of vitamin D intake for CVD events and all-cause mortality after >20 years of follow-up was examined. Logistic regression and general linear regression were used for data analysis.

Setting

Participants in the UK.

Subjects

Men (n 452) who were free from CVD and type 2 diabetes at recruitment.

Results

Higher vitamin D intake was associated with increased HDL cholesterol (P=0·003) and pulse pressure (P=0·04) and decreased total cholesterol:HDL cholesterol (P=0·008) cross-sectionally at baseline, but the associations were lost during follow-up. Furthermore, higher vitamin D intake was associated with decreased concentration of plasma TAG at baseline (P=0·01) and at the 5-year (P=0·01), but not the 10-year examination. After >20 years of follow-up, vitamin D was not associated with stroke (n 72), myocardial infarctions (n 142), heart failure (n 43) or all-cause mortality (n 281), but was positively associated with increased diastolic blood pressure (P=0·03).

Conclusions

The study supports associations of higher vitamin D intake with lower fasting plasma TAG and higher diastolic blood pressure.

SUBMITTER: Guo J

PROVIDER: S-EPMC10261356 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Vitamin D intake and risk of CVD and all-cause mortality: evidence from the Caerphilly Prospective Cohort Study.

Guo Jing J Cockcroft John R JR Elwood Peter C PC Pickering Janet E JE Lovegrove Julie A JA Givens David I DI

Public health nutrition 20170814 15

<h4>Objective</h4>Prospective data on the associations between vitamin D intake and risk of CVD and all-cause mortality are limited and inconclusive. The aim of the present study was to investigate the associations between vitamin D intake and CVD risk and all-cause mortality in the Caerphilly Prospective Cohort Study.<h4>Design</h4>The associations of vitamin D intake with CVD risk markers were examined cross-sectionally at baseline and longitudinally at 5-year, 10-year and >20-year follow-ups. ...[more]

PMID: 28803595

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Project description:ObjectiveIsoflavones, a group of soybean nutrients, have been found to provide a wide range of benefits to the human body. The prospective cohort study aims to examine the association of dietary intake of isoflavones with all-cause mortality and heart disease mortality in the US.Materials and methodsIn this study, We conducted to explore the potential correlation of isoflavones (total isoflavones, genistein, and daidzein) intake with the risk of all-cause mortality and heart disease mortality. The mortality status and the heart disease cause of death were determined by NHANES-linked National Death Index public access files through December 31, 2019. The association of dietary isoflavones intake with all-cause mortality and heart disease mortality was analyzed by multivariate Cox regression model to compute hazard ratio (HR) and 95% confidence interval (CI), with adjustment for some demographic characteristics, lifestyle factors, and comorbidities. In addition, we employed Kaplan-Meier curves, subgroups and restricted cubic spline models to assess the effect of dietary isoflavones in different circumstances.ResultThe final study population was 11,979 participants, with 1423 participants determined as deceased (7.95%). After adjusting for multiple variables, the study identified an inverse relationship between total isoflavones [Hazard Ratio (HR) 0.85, 95% CI: 0.74-0.99], genistein [HR 0.82, 95% CI: 0.69-0.98], daidzein [HR 0.81, 95% CI: 0.70-0.94] and the incidence of all-cause mortality. Similarly, only high levels of intake daidzein [HR 0.73, 95% CI: 0.53-0.99] were no significantly associated with heart disease mortality. Additionally, a non-linear relationship was observed between dietary isoflavones and all-cause mortality in female participants (p-value for nonlinear < 0.05 and p-value for overall < 0.05).ConclusionOur findings suggest dietary intake of total isoflavones, genistein, and daidzein in the right amounts was associated with lower all-cause mortality and exhibited an association of results for mortality from heart disease with daidzein to diminish the chances of heart disease mortality. The present study reveals a U-shaped association between dietary isoflavones and all-cause mortality in female participants.

Project description:BackgroundGenetic variants that affect alcohol use in East Asian populations could help assess the causal effects of alcohol consumption on cause-specific mortality. We aimed to investigate the associations between alcohol intake and cause-specific mortality using conventional and genetic epidemiological methods among more than 512 000 adults in China.MethodsThe prospective China Kadoorie Biobank cohort study enrolled 512 724 adults (210 205 men and 302 519 women) aged 30-79 years, during 2004-08. Residents with no major disabilities from ten diverse urban and rural areas of China were invited to participate, and alcohol use was self-reported. During 12 years of follow-up, 56 550 deaths were recorded through linkage to death registries, including 23 457 deaths among 168 050 participants genotyped for ALDH2-rs671 and ADH1B-rs1229984. Adjusted hazard ratios (HRs) for cause-specific mortality by self-reported and genotype-predicted alcohol intake were estimated using Cox regression.Findings33% of men drank alcohol most weeks. In conventional observational analyses, ex-drinkers, non-drinkers, and heavy drinkers had higher risks of death from most major causes than moderate drinkers. Among current drinkers, each 100 g/week higher alcohol intake was associated with higher mortality risks from cancers (HR 1·18 [95% CI 1·14-1·22]), cardiovascular disease (CVD; HR 1·19 [1·15-1·24]), liver diseases (HR 1·51 [1·27-1·78]), non-medical causes (HR 1·15 [1·08-1·23]), and all causes (HR 1·18 [1·15-1·20]). In men, ALDH2-rs671 and ADH1B-rs1229984 genotypes predicted 60-fold differences in mean alcohol intake (4 g/week in the lowest group vs 255 g/week in the highest). Genotype-predicted alcohol intake was uniformly and positively associated with risks of death from all causes (n=12 939; HR 1·07 [95% CI 1·05-1·10]) and from pre-defined alcohol-related cancers (n=1274; 1·12 [1·04-1·21]), liver diseases (n=110; 1·31 [1·02-1·69]), and CVD (n=6109; 1·15 [1·10-1·19]), chiefly due to stroke (n=3285; 1·18 [1·12-1·24]) rather than ischaemic heart disease (n=2363; 1·06 [0·99-1·14]). Results were largely consistent using a polygenic score to predict alcohol intake, with higher intakes associated with higher risks of death from alcohol-related cancers, CVD, and all causes. Approximately 2% of women were current drinkers, and although power was low to assess observational associations of alcohol with mortality, the genetic evidence suggested that the excess risks in men were due to alcohol, not pleiotropy.InterpretationHigher alcohol intake increased the risks of death overall and from major diseases for men in China. There was no genetic evidence of protection from moderate drinking for all-cause and cause-specific mortality, including CVD.FundingKadoorie Charitable Foundation, National Natural Science Foundation of China, British Heart Foundation, Cancer Research UK, GlaxoSmithKline, Wellcome Trust, Medical Research Council, and Chinese Ministry of Science and Technology.

Dataset Information

Vitamin D intake and risk of CVD and all-cause mortality: evidence from the Caerphilly Prospective Cohort Study.

Objective

Design

Setting

Subjects

Results

Conclusions

Publications

Vitamin D intake and risk of CVD and all-cause mortality: evidence from the Caerphilly Prospective Cohort Study.

Similar Datasets

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