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Isolation of an essential Schizosaccharomyces pombe gene, prp31(+), that links splicing and meiosis.

ABSTRACT: We carried out a screen for mutants that arrest prior to premeiotic S phase. One of the strains we isolated contains a temperature-sensitive allele mutation in the fission yeast prp31(+) gene. The prp31-E1 mutant is defective in vegetative cell growth and in meiotic progression. It is synthetically lethal with prp6 and displays a pre-mRNA splicing defect at the restrictive temperature. We cloned the wild-type gene by complementation of the temperature-sensitive mutant phenotype. Prp31p is closely related to human and budding yeast PRP31 homologs and is likely to function as a general splicing factor in both vegetative growth and sexual differentiation.

SUBMITTER: Bishop DT 

PROVIDER: S-EPMC102626 | biostudies-literature | 2000 Jun

REPOSITORIES: biostudies-literature

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SIDS, abnormal nighttime REM sleep and CNS immaturity.

Cornwell A C AC   Feigenbaum P P   Kim A A  

Neuropediatrics 19980401 2

SIDS (Sudden Infant Death Syndrome) is the major cause of death in young, apparently healthy, infants, yet its etiology and pathogenesis remain unknown. SIDS peaks at 2-4 months, is more prevalent in the winter months and typically occurs in the early morning hours when most babies are asleep, suggesting that sleep may be part of the pathophysiological mechanism of SIDS. The sleep patterns of infants at high risk for SIDS were analyzed to test the hypothesis that there are abnormalities specific  ...[more]