Dataset Information

Long-term survival of breast cancer patients with brain metastases: subanalysis of the BMBC registry.

ABSTRACT:

Background

Up to 30% of metastatic breast cancer (BC) patients develop brain metastases (BM). Prognosis of patients with BM is poor and long-term survival is rare. Identification of factors associated with long-term survival is important for improving treatment modalities.

Patients and methods

A total of 2889 patients of the national registry for BM in BC (BMBC) were available for this analysis. Long-term survival was defined as overall survival (OS) in the upper third of the failure curve resulting in a cut-off of 15 months. A total of 887 patients were categorized as long-term survivors.

Results

Long-term survivors compared to other patients were younger at BC and BM diagnosis (median 48 versus 54 years and 53 versus 59 years), more often had HER2-positive tumors (59.1% versus 36.3%), less frequently luminal-like (29.1% versus 35.7%) or triple-negative breast cancer (TNBC) (11.9% versus 28.1%), showed better Eastern Cooperative Oncology Group (ECOG) performance status (PS) at the time of BM diagnosis (ECOG 0-1, 76.9% versus 51.0%), higher pathological complete remission rates after neoadjuvant chemotherapy (21.6% versus 13.7%) and lower number of BM (n = 1, BM 40.9% versus 25.4%; n = 2-3, BM 26.5% versus 26.7%; n ≥4, BM 32.6% versus 47.9%) (P < 0.001). Long-term survivors had leptomeningeal metastases (10.4% versus 17.5%) and extracranial metastases (ECM, 73.6% versus 82.5%) less frequently, and asymptomatic BM more often at the time of BM diagnosis (26.5% versus 20.1%), (P < 0.001). Median OS in long-term survivors was about two times higher than the cut-off of 15 months: 30.9 months [interquartile range (IQR) 30.3] overall, 33.9 months (IQR 37.1) in HER2-positive, 26.9 months (IQR 22.0) in luminal-like and 26.5 months (IQR 18.2) in TNBC patients.

Conclusions

In our analysis, long-term survival of BC patients with BM was associated with better ECOG PS, younger age, HER2-positive subtype, lower number of BM and less extended visceral metastases. Patients with these clinical features might be more eligible for extended local brain and systemic treatment.

SUBMITTER: Riecke K

PROVIDER: S-EPMC10265610 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature

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Publications

Long-term survival of breast cancer patients with brain metastases: subanalysis of the BMBC registry.

Riecke K K Müller V V Neunhöffer T T Park-Simon T-W TW Weide R R Polasik A A Schmidt M M Puppe J J Mundhenke C C Lübbe K K Hesse T T Thill M M Wuerstlein R R Denkert C C Decker T T Fehm T T Nekljudova V V Rey J J Loibl S S Laakmann E E Witzel I I

ESMO open 20230417 3

<h4>Background</h4>Up to 30% of metastatic breast cancer (BC) patients develop brain metastases (BM). Prognosis of patients with BM is poor and long-term survival is rare. Identification of factors associated with long-term survival is important for improving treatment modalities.<h4>Patients and methods</h4>A total of 2889 patients of the national registry for BM in BC (BMBC) were available for this analysis. Long-term survival was defined as overall survival (OS) in the upper third of the fail ...[more]

PMID: 37075697

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Dataset Information

Long-term survival of breast cancer patients with brain metastases: subanalysis of the BMBC registry.

Background

Patients and methods

Results

Conclusions

Publications

Long-term survival of breast cancer patients with brain metastases: subanalysis of the BMBC registry.

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