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ABSTRACT: Purpose
Most patient-reported outcome measures used in ophthalmology show floor effects in a very low vision population, which limits their use in vision restoration trials. The Impact of Vision Impairment-Very Low Vision scale (IVI-VLV) was developed to specifically target a very low vision population, but its test-retest reliability has not been investigated yet.Methods
The German version of the IVI-VLV was administered twice to patients with stable disease of a low vision clinic. Test and retest person measures of the IVI-VLV subscales were obtained from Rasch analysis. Test-retest reliability was investigated by intraclass correlation coefficients and Bland-Altman plots.Results
We included 134 patients (72 women, 62 men) at a mean age of 62 ± 15 years. The intraclass correlation coefficients were 0.920 (95% confidence interval, 0.888-0.944) for the activities of daily living and mobility subscale of the IVI-VLV and 0.929 (95% confidence interval, 0.899-0.949) for the emotional well-being subscale. Bland-Altman plots did not indicate any systematic bias. In linear regression analysis, test-retest differences were not significantly associated with visual acuity or administration interval.Conclusions
Both subscales of the IVI-VLV showed excellent repeatability independent of visual acuity and length of repeat interval. Further validation steps including an assessment of the patient-reported outcome measure's responsiveness are required for use in vision restoration trials.Translational relevance
The results support repeated use of the IVI-VLV as a patient-reported end point in future studies in very low and ultralow vision populations.
SUBMITTER: Fink DJ
PROVIDER: S-EPMC10266551 | biostudies-literature | 2023 Jun
REPOSITORIES: biostudies-literature
Fink David J DJ Terheyden Jan H JH Pondorfer Susanne G SG Holz Frank G FG Finger Robert P RP
Translational vision science & technology 20230601 6
<h4>Purpose</h4>Most patient-reported outcome measures used in ophthalmology show floor effects in a very low vision population, which limits their use in vision restoration trials. The Impact of Vision Impairment-Very Low Vision scale (IVI-VLV) was developed to specifically target a very low vision population, but its test-retest reliability has not been investigated yet.<h4>Methods</h4>The German version of the IVI-VLV was administered twice to patients with stable disease of a low vision clin ...[more]