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Circadian rhythm disruption linked to skeletal muscle dysfunction in the Mexican Cavefish.

ABSTRACT: It has become clear that circadian clocks in peripheral tissues play important functions. Disruption of the circadian clock in skeletal muscle, for example, results in insulin resistance, sarcomere disorganization, and muscle weakness¹. Interestingly, cavefish, which exhibit a disrupted central clock, exhibit similar muscle phenotypes²^,³^,⁴, raising the question of whether they are caused by alterations to central or peripheral clocks. Here, we demonstrate a loss in clock function in the skeletal muscle of the Mexican Cavefish Astyanax mexicanus that is associated with reduced rhythmicity of a large number of genes and disrupted nocturnal protein catabolism. Some of the identified genes are associated with metabolic dysfunction in humans.

SUBMITTER: Olsen L

PROVIDER: S-EPMC10266680 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature

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Circadian rhythm disruption linked to skeletal muscle dysfunction in the Mexican Cavefish.

Olsen Luke L Krishnan Jaya J Banks Charles C Hassan Huzaifa H Rohner Nicolas N

Current biology : CB 20230401 7

It has become clear that circadian clocks in peripheral tissues play important functions. Disruption of the circadian clock in skeletal muscle, for example, results in insulin resistance, sarcomere disorganization, and muscle weakness1. Interestingly, cavefish, which exhibit a disrupted central clock, exhibit similar muscle phenotypes2,3,4, raising the question of whether they are caused by alterations to central or peripheral clo ...[more]

PMID: 37040703

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