Mendelian randomization indicates that atopic dermatitis contributes to the occurrence of diabetes.

ABSTRACT:

Background

An association has been indicated between atopic dermatitis (AD), a prevalent chronic inflammatory skin disease, and diabetes mellitus. However, the exact causal relationship between AD and both type 1 diabetes (T1D) and type 2 diabetes (T2D) remains controversial. This study aimed to explore the causal association between AD and diabetes by Mendelian Randomization (MR) approaches.

Methods

Public genetic summary data for AD was obtained from EAGLE study. Single nucleotide polymorphisms of diabetes were retrieved from four genome-wide association studies that had been performed in European populations. Inverse variance weighted (IVW) in MR analysis was used as the primary means of causality estimation. Several complementary analyses and sensitivity analyses were pe

SUBMITTER: Lu F 

PROVIDER: S-EPMC10268454 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature