Ontology highlight
ABSTRACT:
SUBMITTER: Huang XY
PROVIDER: S-EPMC10276878 | biostudies-literature | 2023 Jun
REPOSITORIES: biostudies-literature
Huang Xing-Yao XY Chen Qi Q Sun Meng-Xu MX Zhou Hang-Yu HY Ye Qing Q Chen Wu W Peng Jin-Yu JY Qi Yi-Ni YN Zhai Jun-Qiong JQ Tian Ying Y Liu Zi-Xin ZX Huang Yi-Jiao YJ Deng Yong-Qiang YQ Li Xiao-Feng XF Wu Aiping A Yang Xiao X Yang Guan G Shen Yongyi Y Qin Cheng-Feng CF
Cell discovery 20230617 1
Virus spillover remains a major challenge to public health. A panel of SARS-CoV-2-related coronaviruses have been identified in pangolins, while the infectivity and pathogenicity of these pangolin-origin coronaviruses (pCoV) in humans remain largely unknown. Herein, we comprehensively characterized the infectivity and pathogenicity of a recent pCoV isolate (pCoV-GD01) in human cells and human tracheal epithelium organoids and established animal models in comparison with SARS-CoV-2. pCoV-GD01 sho ...[more]