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Focal therapy of prostate cancer: Assessment with prostate-specific membrane antigen (PSMA) imaging.


ABSTRACT: Focal therapy of prostate cancer (PCa) is currently of great interest, but a metric of success. other than biopsy, is not yet available. In a patient with a repeatedly negative MRI and negative systematic biopsies, a scan employing the radioisotope 68Ga-PSMA-11 PET/CT identified a PSMA-avid hotspot in the prostate. PSMA-guided biopsy confirmed the diagnosis of a clinically-significant PCa. Following ablation of the lesion with high-intensity focused ultrasound (HIFU), the PSMA-avid lesion disappeared and targeted biopsy confirmed a fibrotic scar with no residual cancer. PSMA imaging may have a role in guiding diagnosis, focal ablation, and follow-up of men with PCa.

SUBMITTER: Topoozian M 

PROVIDER: S-EPMC10285561 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature

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Focal therapy of prostate cancer: Assessment with prostate-specific membrane antigen (PSMA) imaging.

Topoozian Mark M   Calais Jeremie J   Felker Ely E   Sisk Anthony A   Gonzalez Samantha S   Lee Sean J SJ   Marks Leonard S LS  

Urology case reports 20230609


Focal therapy of prostate cancer (PCa) is currently of great interest, but a metric of success. other than biopsy, is not yet available. In a patient with a repeatedly negative MRI and negative systematic biopsies, a scan employing the radioisotope <sup>68</sup>Ga-PSMA-11 PET/CT identified a PSMA-avid hotspot in the prostate. PSMA-guided biopsy confirmed the diagnosis of a clinically-significant PCa. Following ablation of the lesion with high-intensity focused ultrasound (HIFU), the PSMA-avid le  ...[more]

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