Dataset Information

Quiescence during burst suppression and postictal generalized EEG suppression are distinct patterns of activity.

ABSTRACT:

Objective

Periods of low-amplitude electroencephalographic (EEG) signal (quiescence) are present during both anesthetic-induced burst suppression (BS) and postictal generalized electroencephalographic suppression (PGES). PGES following generalized seizures induced by electroconvulsive therapy (ECT) has been previously linked to antidepressant response. The commonality of quiescence during both BS and PGES motivated trials to recapitulate the antidepressant effects of ECT using high doses of anesthetics. However, there have been no direct electrographic comparisons of these quiescent periods to address whether these are distinct entities.

Methods

We compared periods of EEG quiescence recorded from two human studies: BS induced in 29 healthy adult volunteers by isoflurane general anesthesia and PGES in 11 patients undergoing right unilateral ECT for treatment-resistant depression. An automated algorithm allowed detection of EEG quiescence based on a 10-microvolt amplitude threshold. Spatial, spectral, and temporal analyses compared quiescent epochs during BS and PGES.

Results

The median (interquartile range) voltage for quiescent periods during PGES was greater than during BS (1.81 (0.22) microvolts vs 1.22 (0.33) microvolts, p < 0.001). Relative power was greater for quiescence during PGES than BS for the 1-4 Hz delta band (p < 0.001), at the expense of power in the theta (4-8 Hz, p < 0.001), beta (13-30 Hz, p = 0.04) and gamma (30-70 Hz, p = 0.006) frequency bands. Topographic analyses revealed that amplitude across the scalp was consistently higher for quiescent periods during PGES than BS, whose voltage was within the noise floor.

Conclusions

Quiescent epochs during PGES and BS have distinct patterns of EEG signals across voltage, frequency, and spatial domains.

Significance

Quiescent epochs during PGES and BS, important neurophysiological markers for clinical outcomes, are shown to have distinct voltage and frequency characteristics.

SUBMITTER: Kafashan M

PROVIDER: S-EPMC10287541 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature

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Publications

Quiescence during burst suppression and postictal generalized EEG suppression are distinct patterns of activity.

Kafashan MohammadMehdi M Brian Hickman L L Labonte Alyssa K AK Huels Emma R ER Maybrier Hannah H Guay Christian S CS Subramanian Subha S Farber Nuri B NB Ching ShiNung S Hogan R Edward RE Kelz Max B MB Avidan Michael S MS Mashour George A GA Palanca Ben J A BJA

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology 20220730

<h4>Objective</h4>Periods of low-amplitude electroencephalographic (EEG) signal (quiescence) are present during both anesthetic-induced burst suppression (BS) and postictal generalized electroencephalographic suppression (PGES). PGES following generalized seizures induced by electroconvulsive therapy (ECT) has been previously linked to antidepressant response. The commonality of quiescence during both BS and PGES motivated trials to recapitulate the antidepressant effects of ECT using high doses ...[more]

PMID: 36030576

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Dataset Information

Quiescence during burst suppression and postictal generalized EEG suppression are distinct patterns of activity.

Objective

Methods

Results

Conclusions

Significance

Publications

Quiescence during burst suppression and postictal generalized EEG suppression are distinct patterns of activity.

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