Aquaporins and CO₂ diffusion across biological membrane.

ABSTRACT: Despite the physiological significance of effective CO₂ diffusion across biological membranes, the underlying mechanism behind this process is not yet resolved. Particularly debatable is the existence of CO₂-permeable aquaporins. The lipophilic characteristic of CO₂ should, according to Overton's rule, result in a rapid flux across lipid bilayers. However, experimental evidence of limited membrane permeability poses a challenge to this idea of free diffusion. In this review, we summarized recent progress with regard to CO₂ diffusion, and discussed the physiological effects of altered aquaporin expression, the molecular mechanisms of CO₂ transport via aquaporins, and the function of sterols and other membrane proteins in CO₂ permeability. In addition, we highlight the existing limits in measuring CO₂ permeability and end up with perspectives on resolving such argument either by determining the atomic resolution structure of CO₂ permeable aquaporins or by developing new methods for measuring permeability.

SUBMITTER: Chen J 

PROVIDER: S-EPMC10293838 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature