Ontology highlight
ABSTRACT:
SUBMITTER: Grenier SF
PROVIDER: S-EPMC10298379 | biostudies-literature | 2023 Jun
REPOSITORIES: biostudies-literature
Grenier Shea F SF Khan Mohammad W MW Reil Katherine A KA Sawaged Savannah S Tsuji Shingo S Giacalone Matthew J MJ Tian Mengxi M McGuire Kathleen L KL
International journal of molecular sciences 20230610 12
Colorectal cancer (CRC) remains the third most common form of cancer and, despite its reduced mortality, results in over 50,000 deaths annually, highlighting the need for novel therapeutic approaches. VAX014 is a novel clinical-stage, oncolytic bacterial minicell-based therapy shown to elicit protective antitumor immune responses in cancer, but it has not been fully evaluated in CRC. Here, VAX014 was demonstrated to induce oncolysis in CRC cell lines in vitro and was evaluated in vivo, both as a ...[more]