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A Protein Asteroid with PIN Domain in Silkworm Bombyx mori Is Involved in Anti-BmNPV Infection.

ABSTRACT: Nuclease is a type of protein that degrades nucleic acids, which plays an important role in biological processes, including RNA interference efficiency and antiviral immunity. However, no evidence of a link between nuclease and Bombyx mori nucleopolyhedrovirus (BmNPV) infection in silkworm B. mori has been found. In this study, a protein asteroid (BmAst) containing the PIN domain and XPG domain was identified in silkworm B. mori. BmAst gene was highest expressed in hemocytes and fat body of the 5th instar larvae, and high expression in the pupa stage. The transcriptional levels of the BmAst gene in 5th instar larvae were significantly induced by BmNPV or dsRNA. After knocking down BmAst gene expression by specific dsRNA, the proliferation of BmNPV in B. mori was increased significantly, whereas the survival rate of larvae was significantly lower when compared with the control. Our findings indicate that BmAst is involved in silkworm resistance to BmNPV infection.

SUBMITTER: Xia Y 

PROVIDER: S-EPMC10298989 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature

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A Protein Asteroid with PIN Domain in Silkworm <i>Bombyx mori</i> Is Involved in Anti-BmNPV Infection.

Xia Yuchen Y   Jiang Mouzhen M   Hu Xiaoxuan X   Wang Qing Q   Qian Cen C   Zhu Baojian B   Wei Guoqing G   Wang Lei L  

Insects 20230613 6

Nuclease is a type of protein that degrades nucleic acids, which plays an important role in biological processes, including RNA interference efficiency and antiviral immunity. However, no evidence of a link between nuclease and <i>Bombyx mori</i> nucleopolyhedrovirus (BmNPV) infection in silkworm <i>B. mori</i> has been found. In this study, a protein asteroid (BmAst) containing the PIN domain and XPG domain was identified in silkworm <i>B. mori</i>. <i>BmAst</i> gene was highest expressed in he  ...[more]

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