Ontology highlight
ABSTRACT:
SUBMITTER: Co JY
PROVIDER: S-EPMC10300005 | biostudies-literature | 2023 Jun
REPOSITORIES: biostudies-literature
Co Julia Y JY Klein Jessica A JA Kang Serah S Homan Kimberly A KA
Scientific reports 20230627 1
Primary tissue-derived epithelial organoids are a physiologically relevant in vitro intestinal model that have been implemented for both basic research and drug development applications. The existing method of culturing intestinal organoids in surface-attached native extracellular matrix (ECM) hydrogel domes is not readily amenable to large-scale culture and contributes to culture heterogeneity. We have developed a method of culturing intestinal organoids within suspended basement membrane extra ...[more]