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Rottlerin-Liposome Inhibits the Endocytosis of Feline Coronavirus Infection.

ABSTRACT: Rottlerin (R) is a natural extract from Mallotus philippensis with antiviral properties. Feline infectious peritonitis (FIP) is a fatal disease caused by feline coronavirus (FCoV) that is characterized by systemic granulomatous inflammation and high mortality. We investigated the antiviral effect of liposome-loaded R, i.e., rottlerin-liposome (RL), against FCoV. We demonstrated that RL inhibited FCoV replication in a dose-dependent manner, not only in the early endocytosis stage but also in the late stage of replication. RL resolved the low solubility issue of rottlerin and improved its inhibition efficacy at the cellular level. Based on these findings, we suggest that RL is worth further investigation as a potential treatment for FCoV.

SUBMITTER: Choi JC

PROVIDER: S-EPMC10302841 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature

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Rottlerin-Liposome Inhibits the Endocytosis of Feline Coronavirus Infection.

Choi Jong-Chul JC Jung Sung-Won SW Choi In-Yeong IY Kang Yeong-Lim YL Lee Dong-Hun DH Lee Sang-Won SW Park Seung-Yong SY Song Chang-Seon CS Choi In-Soo IS Lee Joong-Bok JB Oh Changin C

Veterinary sciences 20230530 6

Rottlerin (R) is a natural extract from <i>Mallotus philippensis</i> with antiviral properties. Feline infectious peritonitis (FIP) is a fatal disease caused by feline coronavirus (FCoV) that is characterized by systemic granulomatous inflammation and high mortality. We investigated the antiviral effect of liposome-loaded R, i.e., rottlerin-liposome (RL), against FCoV. We demonstrated that RL inhibited FCoV replication in a dose-dependent manner, not only in the early endocytosis stage but also ...[more]

PMID: 37368766

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