Dataset Information

Effect measure modification of the association between short-term exposures to PM_2.5 and hospitalizations by longs-term PM_2.5 exposure among a cohort of people with Chronic Obstructive Pulmonary Disease (COPD) in North Carolina, 2002-2015.

ABSTRACT:

Background

Approximately nine million adults in the United States are living with chronic obstructive pulmonary disease (COPD), and positive associations between short-term air pollution exposure and increased risk of COPD hospitalizations in older adults are consistently reported. We examined the association between short-term PM_2.5 exposure and hospitalizations and assessed if there is modification by long-term exposure in a cohort of individuals with COPD.

Methods

In a time-referent case-crossover design, we used a cohort of randomly selected individuals with electronic health records from the University of North Carolina Healthcare System, restricted to patients with a medical encounter coded with a COPD diagnosis from 2004-2016 (n = 520), and estimated ambient PM_2.5 concentrations from an ensemble model. Odds ratios and 95% confidence intervals (OR (95%CI)) were estimated with conditional logistic regression for respiratory-related, cardiovascular (CVD), and all-cause hospitalizations. Exposures examined were 0-2 and 0-3 day lags of PM_2.5 concentration, adjusting for daily census-tract temperature and humidity, and models were stratified by long-term (annual average) PM_2.5 concentration at the median value.

Results

We observed generally null or low-magnitude negative associations with short-term PM_2.5 exposure and respiratory-related (OR per 5 µg/m³ increase in 3-day lag PM_2.5: 0.971 (0.885, 1.066)), CVD (2-day lag: 0.976 (0.900, 1.058) and all-cause (3 day lag: 1.003 (0.927, 1.086)) hospitalizations. Associations between short-term PM_2.5 exposure and hospitalizations were higher among patients residing in areas with higher levels of annual PM_2.5 concentrations (OR per 5 µg/m³ in 3-day lag PM_2.5 for all-cause hospitalizations: 1.066 (0.958, 1.185)) than those in areas with lower annual PM_2.5 concentrations (OR per 5 µg/m³ in 3-day lag PM_2.5 for all-cause hospitalizations: 0.914 (0.804, 1.039)).

Concluisons

Differences in associations demonstrate that people in areas with higher annual PM_2.5 exposure may be associated with higher risk of hospitalization during short-term increases in PM_2.5 exposure.

SUBMITTER: Cowan KN

PROVIDER: S-EPMC10308617 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature

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Publications

Effect measure modification of the association between short-term exposures to PM<sub>2.5</sub> and hospitalizations by longs-term PM<sub>2.5</sub> exposure among a cohort of people with Chronic Obstructive Pulmonary Disease (COPD) in North Carolina, 2002-2015.

Cowan Kristen N KN Wyatt Lauren H LH Luben Thomas J TJ Sacks Jason D JD Ward-Caviness Cavin C Rappazzo Kristen M KM

Environmental health : a global access science source 20230629 1

<h4>Background</h4>Approximately nine million adults in the United States are living with chronic obstructive pulmonary disease (COPD), and positive associations between short-term air pollution exposure and increased risk of COPD hospitalizations in older adults are consistently reported. We examined the association between short-term PM<sub>2.5</sub> exposure and hospitalizations and assessed if there is modification by long-term exposure in a cohort of individuals with COPD.<h4>Methods</h4>In ...[more]

PMID: 37386433

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Dataset Information

Effect measure modification of the association between short-term exposures to PM_2.5 and hospitalizations by longs-term PM_2.5 exposure among a cohort of people with Chronic Obstructive Pulmonary Disease (COPD) in North Carolina, 2002-2015.

Background

Methods

Results

Concluisons

Publications

Effect measure modification of the association between short-term exposures to PM<sub>2.5</sub> and hospitalizations by longs-term PM<sub>2.5</sub> exposure among a cohort of people with Chronic Obstructive Pulmonary Disease (COPD) in North Carolina, 2002-2015.

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OmicsDI is part of the ELIXIR infrastructure

Tweets

Dataset Information

Effect measure modification of the association between short-term exposures to PM2.5 and hospitalizations by longs-term PM2.5 exposure among a cohort of people with Chronic Obstructive Pulmonary Disease (COPD) in North Carolina, 2002-2015.

Background

Methods

Results

Concluisons

Publications

Effect measure modification of the association between short-term exposures to PM<sub>2.5</sub> and hospitalizations by longs-term PM<sub>2.5</sub> exposure among a cohort of people with Chronic Obstructive Pulmonary Disease (COPD) in North Carolina, 2002-2015.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Effect measure modification of the association between short-term exposures to PM_2.5 and hospitalizations by longs-term PM_2.5 exposure among a cohort of people with Chronic Obstructive Pulmonary Disease (COPD) in North Carolina, 2002-2015.