Ontology highlight
ABSTRACT:
SUBMITTER: Schmolka N
PROVIDER: S-EPMC10310694 | biostudies-literature | 2023 Jun
REPOSITORIES: biostudies-literature
Schmolka Nina N Karemaker Ino D ID Cardoso da Silva Richard R Recchia Davide C DC Spegg Vincent V Bhaskaran Jahnavi J Teske Michael M de Wagenaar Nathalie P NP Altmeyer Matthias M Baubec Tuncay T
Nature communications 20230629 1
The Nucleosome Remodeling and Deacetylation (NuRD) complex is a crucial regulator of cellular differentiation. Two members of the Methyl-CpG-binding domain (MBD) protein family, MBD2 and MBD3, are known to be integral, but mutually exclusive subunits of the NuRD complex. Several MBD2 and MBD3 isoforms are present in mammalian cells, resulting in distinct MBD-NuRD complexes. Whether these different complexes serve distinct functional activities during differentiation is not fully explored. Based ...[more]