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ABSTRACT: Background
The CLinical Assessment of WEB device in Ruptured aneurYSms (CLARYS) study has shown that the endovascular treatment of ruptured bifurcation aneurysms with the Woven EndoBridge (WEB) is safe and effective and provides protection against rebleeding at 1 month and 1 year. The 12-month angiographic follow-up is an important endpoint of the study.Methods
The CLARYS study is a prospective multicenter study conducted in 13 European centers. The study enrolled 60 patients with 60 ruptured aneurysms of the anterior and posterior circulation. The study was conducted with an independent assessment of safety outcomes and imaging.Results
Sixty patients with 60 ruptured bifurcation aneurysms to be treated with the WEB were included. Fifty-three aneurysms (88.3%) had a broad base with a dome to neck ratio <2 (mean 1.6). Of these, 46 patients were evaluated by an independent core laboratory with follow-up imaging performed at 12 months or before eventual retreatment. At 1 year, 19/46 aneurysms (41.3%) were completely occluded (Raymond-Roy grade I), 21/46 (45.7%) had a residual neck and 6/46 (13.0%) had residual aneurysm filling. Adequate occlusion was reported in 40/46 (87%) aneurysms. Six patients underwent target aneurysm retreatment.Conclusions
The CLARYS study has previously shown that the use of the WEB in the endovascular treatment of ruptured bifurcation aneurysms provides effective protection against rebleeding with a good safety profile. The angiographic occlusion rates at 1 year reported here are comparable to those already seen in previous multicenter studies which primarily included unruptured aneurysms.
SUBMITTER: Spelle L
PROVIDER: S-EPMC10314057 | biostudies-literature | 2023 Jul
REPOSITORIES: biostudies-literature
Spelle Laurent L Herbreteau Denis D Caroff Jildaz J Barreau Xavier X Ferré Jean-Christophe JC Fiehler Jens J Januel Anne-Christine AC Costalat Vincent V Liebig Thomas T Bourcier Romain R Möhlenbruch Markus A MA Berkefeld Joachim J Weber Werner W Mihalea Cristian C Ikka Léon L Ozanne Augustin A Cognard Christophe C Narata Ana Paula AP Bibi Richard Edwige RE Gauvrit Jean-Yves JY Raoult Hélène H Velasco Stéphane S Buhk Jan-Hendrik JH Chalumeau Vanessa V Bester Maxim M Desal Hubert H du Mesnil de Rochemont Richard R Bohner Georg G Fischer Sebastian S Gallas Sophie S Biondi Alessandra A Grimaldi Lamiae L Moret Jacques J Byrne James J Pierot Laurent L
Journal of neurointerventional surgery 20220726 7
<h4>Background</h4>The CLinical Assessment of WEB device in Ruptured aneurYSms (CLARYS) study has shown that the endovascular treatment of ruptured bifurcation aneurysms with the Woven EndoBridge (WEB) is safe and effective and provides protection against rebleeding at 1 month and 1 year. The 12-month angiographic follow-up is an important endpoint of the study.<h4>Methods</h4>The CLARYS study is a prospective multicenter study conducted in 13 European centers. The study enrolled 60 patients wit ...[more]