Ontology highlight
ABSTRACT:
SUBMITTER: Hong JR
PROVIDER: S-EPMC10320039 | biostudies-literature | 2023 Jun
REPOSITORIES: biostudies-literature
Hong Jie-Ru JR Jin Ling L Zhang Chen-Yu CY Zhong Wen-Jing WJ Yang Hui-Hui HH Wang Guan-Ming GM Ma Sheng-Chao SC Guan Cha-Xiang CX Li Qing Q Zhou Yong Y
Heliyon 20230619 6
Alveolar epithelial cell (AEC) senescence is implicated in the pathogenesis of pulmonary fibrosis (PF). However, the exact mechanism underlying AEC senescence during PF remains poorly understood. Here, we reported an unrecognized mechanism for AEC senescence during PF. We found that, in bleomycin (BLM)-induced PF mice, the expressions of isocitrate dehydrogenase 3α (Idh3α) and citrate carrier (CIC) were significantly down-regulated in the lungs, which could result in mitochondria citrate (citrat ...[more]